Dimethylamine → HCID 20540231, 화합물

HRID 1065266노트

반응식

HRID 1065266 반응식
[CH3:1][NH:2][CH3:3].C(=O)([O-])[O-].[Na+].[Na+].O.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2([C:29](Cl)=[O:30])[CH2:28][CH2:27][C:22]3([O:26][CH2:25][CH2:24][O:23]3)[CH2:21][CH2:20]2)=[CH:15][CH:14]=1>CC1C=CC=CC=1>[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2([C:29]([N:2]([CH3:3])[CH3:1])=[O:30])[CH2:28][CH2:27][C:22]3([O:26][CH2:25][CH2:24][O:23]3)[CH2:21][CH2:20]2)=[CH:15][CH:14]=1

참가 물질

6

반응물 4

HCID 674DimethylamineHCID 962WaterHCID 10340Sodium CarbonateHCID 20540243HCID 20540243, 화합물

생성물 1

HCID 20540231HCID 20540231, 화합물수율 100%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a stirred and cooled (<0° C.) mixture of 49.5 parts of N-methylmethanamine solution 40%, 93 parts of sodium carbonate and 1000 parts of water is added dropwise a solution of 124 parts of 8-(4-methoxyphenyl)-1,4-dioxaspiro[4,5]decane-8-carbonyl chloride in 675 parts of methylbenzene. Upon completion, stirring is continued overnight at room temperature. The layers are separated and the organic phase is washed with water, dried, filtered and evaporated, yielding 128 parts (100%) of 8-(4-methoxyphenyl)-N,N-dimethyl-1,4-dioxaspiro[4,5]decane-8-carboxamide as a residue.

후처리

  1. temperaturecooled
  2. stirringUpon completion, stirring
  3. customThe layers are separated
  4. washthe organic phase is washed with water
  5. customdried
  6. filtrationfiltered
  7. customevaporated

출처 및 근거

ORD 기록
ord-57636b6782d74dd7b10a71b904a9c14c
출처 데이터셋
uspto-grants-1982_05
특허 번호
US04329353

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