7-Hydroxy-3,4-dihydrocarbostyril → 7-(4-(phenylsulfonyl)butoxy)-3,4-dihydroquinolin-2(1H)-one

반응식

[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1.[C:13]1([S:19]([CH2:22][CH2:23][CH2:24][CH2:25]Br)(=[O:21])=[O:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:13]1([S:19]([CH2:22][CH2:23][CH2:24][CH2:25][O:1][C:2]2[CH:11]=[C:10]3[C:5]([CH2:6][CH2:7][C:8](=[O:12])[NH:9]3)=[CH:4][CH:3]=2)(=[O:21])=[O:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

반응물 2

HCID 27857587-Hydroxy-3,4-dihydrocarbostyril

HCID 114827894-Phenylsulfonylbutyl bromide

생성물 1

HCID 205401397-(4-(phenylsulfonyl)butoxy)-3,4-dihydroquinolin-2(1H)-one

실험 절차

Prepared analogous to Example 4 from 7-hydroxy-3,4-dihydro-carbostyril (see N. Shigematsu et al., Chem. Pharm. Bull. 1961, 970-975) and 4-phenylsulfonyl-butyl bromide.

출처 및 근거

ORD 기록: ord-bae4305cf9e2435384d0665f410e2e2a
출처 데이터셋: uspto-grants-1982_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04329347

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