Hydrogen Peroxide → 5-(4-Phenylsulfinyl-butoxy)-carbostyril

HRID 1065371노트

반응식

HRID 1065371 반응식
[OH:1]O.[C:3]1([S:9][CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:24]=[CH:23][CH:22]=[C:21]3[C:16]=2[CH:17]=[CH:18][C:19](=[O:25])[NH:20]3)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C(O)(=O)C.O>[C:3]1([S:9]([CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:24]=[CH:23][CH:22]=[C:21]3[C:16]=2[CH:17]=[CH:18][C:19](=[O:25])[NH:20]3)=[O:1])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

5

반응물 2

HCID 784Hydrogen PeroxideHCID 538402795-(4-Phenylmercapto-butoxy)-carbostyril

생성물 1

HCID 205401285-(4-Phenylsulfinyl-butoxy)-carbostyril

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

실험 절차

0.165 ml of 30% hydrogen peroxide, dissolved in 8 ml of glacial acetic acid, were added to 0.56 gm of 5-(4-phenylmercapto-butoxy)-carbostyril. The mixture was diluted with water and extracted twice with chloroform. The chloroform extract was washed with dilute sodium carbonate solution and with water, dried over magnesium sulfate and evaporated. The residue was admixed with ethyl acetate, yielding colorless crystals with a melting point of 155°-157° C.

후처리

  1. extractionextracted twice with chloroform
  2. extractionThe chloroform extract
  3. washwas washed with dilute sodium carbonate solution and with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated
  6. customyielding colorless crystals with a melting point of 155°-157° C.

출처 및 근거

ORD 기록
ord-6e5d00fc9ec0487eaf7db48c123f4ebf
출처 데이터셋
uspto-grants-1982_05
특허 번호
US04329347

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