Morpholine → HCID 70550960, 화합물

HRID 1065480노트

반응식

HRID 1065480 반응식
[N+:1]([C:4]1[CH:19]=[CH:18][C:7]([CH:8]=[N:9][NH:10][C:11]2[N:12]=[N:13][C:14](Cl)=[CH:15][CH:16]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>CN(C)P(=O)(N(C)C)N(C)C>[N+:1]([C:4]1[CH:19]=[CH:18][C:7]([CH:8]=[N:9][NH:10][C:11]2[N:12]=[N:13][C:14]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[CH:15][CH:16]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 593142HCID 593142, 화합물

생성물 1

HCID 70550960HCID 70550960, 화합물수율 85.3%

시약·촉매·용매 1

HCID 12679Hexamethylphosphoramide용매

실험 절차

The mixture of 5.55 g (20 mmoles) of 4-nitrobenzylidene-(6-chloro-3-pyridazinyl)-hydrazine [prepared by the process described in Step a:], 7.66 g (88 mmoles) of morpholine and 5.5 ml of hexamethylphosphoric cid triamide is heated at 150° C. for 24 hours. After cooling, the mixture is triturated with 56 ml of water, the precipitate is filtered, washed with cold ethanol and dried to give 5.6 g (85%) of the named compound; m.p. 245° C. (with decomposition).

후처리

  1. customprepared by the process
  2. temperatureAfter cooling
  3. customthe mixture is triturated with 56 ml of water
  4. filtrationthe precipitate is filtered
  5. washwashed with cold ethanol
  6. customdried

출처 및 근거

ORD 기록
ord-50e66ff8481545c1857329f3e3d3d8fc
출처 데이터셋
uspto-grants-1982_05
특허 번호
US04329457

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