4-keto-L-proline hydrobromide → 1-[3-(acetylthio)-2-methylthio-1-oxopropyl]-4-oxo-L-proline

반응식

[C:1]([S:4][CH2:5][CH:6]([S:10][CH3:11])[C:7](Cl)=[O:8])(=[O:3])[CH3:2].Br.[O:13]=[C:14]1[CH2:18][NH:17][C@H:16]([C:19]([OH:21])=[O:20])[CH2:15]1.C(SCCC(N1CC(=O)C[C@H]1C(O)=O)=O)(=O)C>>[C:1]([S:4][CH2:5][CH:6]([S:10][CH3:11])[C:7]([N:17]1[CH2:18][C:14](=[O:13])[CH2:15][C@H:16]1[C:19]([OH:21])=[O:20])=[O:8])(=[O:3])[CH3:2]

참가 물질

반응물 3

HCID 127736614-keto-L-proline hydrobromide

HCID 127736631-[3-(Acetylthio)-1-oxopropyl]-4-oxo-L-proline

HCID 543411833-(Acetylthio)-2-(methylthio)propionic acid chloride

생성물 1

HCID 536857661-[3-(acetylthio)-2-methylthio-1-oxopropyl]-4-oxo-L-proline

실험 절차

The 3-(acetylthio)-2-(methylthio)propionic acid chloride is reacted with 4-keto-L-proline, hydrobromide according to the procedure of Example 1 (d) to yield 1-[3-(acetylthio)-2-methylthio-1-oxopropyl]-4-oxo-L-proline.

출처 및 근거

ORD 기록: ord-238b7b5594284274a7deac715cd8662c
출처 데이터셋: uspto-grants-1982_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04330548

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