Phenyl isocyanate → N-(4-pyridazinyl)-N'-phenylurea

HRID 1065941

반응식

HRID 1065941 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[N:4][CH:3]=1.[C:8]1([N:14]=[C:15]=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>CC(C)=O>[N:5]1[CH:6]=[CH:7][C:2]([NH:1][C:15]([NH:14][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:16])=[CH:3][N:4]=1

참가 물질

4

반응물 2

HCID 7672Phenyl isocyanateHCID 2984924-Aminopyridazine

생성물 1

HCID 12893792N-(4-pyridazinyl)-N'-phenylurea

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

200 mg. of 4-aminopyridazine was suspended in 50 ml. of acetone. To the resulting suspension, 1.2 times the amount of phenyl isocyanate theoretically calculated was added and the mixture then reacted at room temperature overnight. The crystals formed were taken out by filtration. By recrystallization from an excess of methanol, N-(4-pyridazinyl)-N'-phenylurea was obtained (yield, greater than 80%); melting point higher than 250° C.

후처리

  1. customthe mixture then reacted at room temperature overnight
  2. customThe crystals formed
  3. filtrationwere taken out by filtration
  4. customBy recrystallization from an excess of methanol

출처 및 근거

ORD 기록
ord-b643778aea364656bc2dd9c46168b1ef
출처 데이터셋
uspto-grants-1982_05
특허 번호
US04331807

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