(R)-(+)-1-Phenylpropyl isocyanate → 4(S)-tert-butyl-2-oxoazetidine-1-carboxylic acid (1(R)-phenylpropyl)amide

HRID 1066022노트

반응식

HRID 1066022 반응식
[C:1]([C@H:5]1[NH:8][C:7](=[O:9])[CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[C:10]1([C@H:16]([N:19]=[C:20]=[O:21])[CH2:17][CH3:18])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[C:10]1([C@H:16]([NH:19][C:20]([N:8]2[C@H:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH2:6][C:7]2=[O:9])=[O:21])[CH2:17][CH3:18])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

3

반응물 2

HCID 7018288(R)-(+)-1-Phenylpropyl isocyanateHCID 206598394(S)-tert-butylazetidine-2-one

생성물 1

HCID 543353084(S)-tert-butyl-2-oxoazetidine-1-carboxylic acid (1(R)-phenylpropyl)amide

실험 절차

Following the same procedure as in example 1, step F, but using 4(S)-tert-butylazetidine-2-one as starting material and 1(R)-phenylpropyl isocyanate as reactant, 4(S)-tert-butyl-2-oxoazetidine-1-carboxylic acid (1(R)-phenylpropyl)amide was obtained as a waxy solid.

출처 및 근거

ORD 기록
ord-bf230b4e366549e49cd6131beedaea89
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06242439B1

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