2-(Benzylamino)-5-(trifluoromethyl)benzenesulfonamide → HCID 11333908, 화합물
반응식
C([NH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:10]=1[S:19]([NH2:22])(=[O:21])=[O:20])C1C=CC=CC=1.[H][H]>CO.[Pd]>[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:17])([F:16])[F:18])=[CH:11][C:10]=1[S:19]([NH2:22])(=[O:21])=[O:20]참가 물질
5
실험 절차
A solution of 2-benzylamino-5-trifluoromethylbenzenesulfonamide (7.3 g) in methanol (80 mL) was supplemented with 10% Pd/C (0.73 g) and submitted to hydrogen under pressure (4 bars) during 90 min. at room temperature. The insoluble material was removed by filtration and the filtrate was concentrated to dryness. The residue was crystallized in methanol-water to give the title compound (yield: 5 g); m.p. 142-143° C.
후처리
- customThe insoluble material was removed by filtration
- concentrationthe filtrate was concentrated to dryness
- customThe residue was crystallized in methanol-water
출처 및 근거
- ORD 기록
- ord-61f40d3017aa402187936c8fcb603b2f
- 출처 데이터셋
- uspto-grants-2001_06
- 특허 번호
- US06242443B1
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