Ammonium Hydroxide → 5-Bromo-2-methoxybenzenesulphonamide
반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][CH3:13])=[C:6]([S:8](Cl)(=[O:10])=[O:9])[CH:7]=1.[NH4+:14].[OH-]>C1COCC1.CCOC(C)=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][CH3:13])=[C:6]([S:8]([NH2:14])(=[O:10])=[O:9])[CH:7]=1참가 물질
5
실험 절차
To 5-bromo-2-methoxybenzenesulfonyl chloride (45g; 157.6 mmol, from Lancaster Chemical) at 0° C. in THF, was added concentrated NH4OH (42.5 mL) and the reaction mixture was brought to r.t. for 2 h. The reaction mixture was diluted with EtOAc, extracted with NaHCO3 (2×), brine, and the organic phase was dried over MgSO4. The solvent was removed to give the title compound.
후처리
- extractionextracted with NaHCO3 (2×), brine
- dry with materialthe organic phase was dried over MgSO4
- customThe solvent was removed
출처 및 근거
- ORD 기록
- ord-d088f16016da428485a0eb1a1e3a4582
- 출처 데이터셋
- uspto-grants-2001_06
- 특허 번호
- US06242493B1
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