참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | tert-Butanol | HCID 6386 | — |
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | p-Tolylacetic acid | HCID 248474 | — |
| 반응물 | 4-Diethylaminopyridine | HCID 11768751 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | tert-Butyl (4-methylphenyl)acetate | HCID 12362014 | — |
반응 단계
450 g (3 mol) of 4-methylphenyl-acetic acid (Aldrich), 1.13 l (12 mol) of tert-butanol and 90 g (0.74 mol) of 4-(N,N-diethylamino)pyridine are dissolved in 2 l of dichloromethane. After addition of 680 g (3.3 mol of dicyclohexylcarbodiimide, dissolved in 400 ml of dichloromethane, the mixture is stirred at 25° C. for 20 h, the precipitated urea is filtered off with suction and washed with 200 ml of dichloromethane, and the organic phase is washed twice each with 500 ml of 2 M hydrochloric acid and water. The organic phase is concentrated and distilled.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06245775B1 |
|---|
| 출처 데이터셋 | uspto-grants-2001_06 |
|---|
| ORD ID | ord-b21a3f78409b4b97a18674c91ff231f6 |
|---|
| 출처 메모 | uspto-grants-2001_06 |
|---|
