Piperidine → 1-(Piperidin-1-yl)-4-(2-fluoro-5-bromobenzyloxy)butane

HRID 1066834노트

반응식

HRID 1066834 반응식
[F:1][C:2]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][CH2:8][CH2:9]Br.[NH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>O1CCCC1.C(Cl)Cl>[N:16]1([CH2:9][CH2:8][CH2:7][CH2:6][O:5][CH2:4][C:3]2[CH:11]=[C:12]([Br:15])[CH:13]=[CH:14][C:2]=2[F:1])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

참가 물질

5

반응물 2

HCID 8082PiperidineHCID 21196139HCID 21196139, 화합물

생성물 1

HCID 211961091-(Piperidin-1-yl)-4-(2-fluoro-5-bromobenzyloxy)butane

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 4-(2-fluoro-5-bromobenzyloxy)butyl bromide (520 mg, 1.53 mmol) in tetrahydrofuran (8 ml) was treated with piperidine (1.5 ml, 15.3 mmol). The resulting reaction mixture was stirred for about 24 hours. The reaction mixture was then diluted with methylene chloride and washed with saturated sodium bicarbonate. The organic fraction was dried over sodium sulfate and the solvents were removed in vacuo. The desired title intermediate was further purified by radial chromatography.

후처리

  1. customThe resulting reaction mixture
  2. washwashed with saturated sodium bicarbonate
  3. dry with materialThe organic fraction was dried over sodium sulfate
  4. customthe solvents were removed in vacuo
  5. customThe desired title intermediate was further purified by radial chromatography

출처 및 근거

ORD 기록
ord-ea1c3d25f6f8406f9103a277347bf27b
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06245761B1

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