Dibenz(b,f)azepine → Carbamazepine

HRID 1067031

반응식

HRID 1067031 반응식
Cl.[NH2:2][C:3]([NH2:5])=[O:4].[CH:6]1[CH:7]=[CH:8][C:9]2N[C:19]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH:13]=[CH:12][C:10]=2[CH:11]=1>C(O)(=O)C>[CH:6]1[CH:7]=[CH:8][C:9]2[N:2]([C:3]([NH2:5])=[O:4])[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[CH:13]=[CH:12][C:10]=2[CH:11]=1

참가 물질

4

반응물 2

HCID 9212Dibenz(b,f)azepineHCID 101721Urea hydrochloride

생성물 1

HCID 2554Carbamazepine

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
27.5 °C

실험 절차

To a suspension of urea hydrochloride (100 g, 1.036 mols) in acetic acid (125 ml), iminostilbene (25 g, 0.129 mols) was added under stirring at 25-30° C. The resulting reaction mixture was worked up according to the method of Example 1 to produce carbamazepine, which was identical to the product of Example 1.

후처리

  1. additionwas added
  2. customThe resulting reaction mixture

출처 및 근거

ORD 기록
ord-8e4456a22a7f49ce952b44e08861db61
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06245908B1

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