4-Hydroxybenzaldehyde → p-((Trimethylsilyl)oxy)benzaldehyde

HRID 1067054

반응식

HRID 1067054 반응식
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.C(N(CC)CC)C.Cl[Si:18]([CH3:21])([CH3:20])[CH3:19].CCCCCC>ClCCl>[CH3:19][Si:18]([CH3:21])([CH3:20])[O:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 1264-HydroxybenzaldehydeHCID 6397ChlorotrimethylsilaneHCID 8058HexaneHCID 8471Triethylamine

생성물 1

HCID 70536p-((Trimethylsilyl)oxy)benzaldehyde

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of 122 g 4-hydroxybenzaldehyde (1.0 mol, available from Aldrich) and 111 g triethylamine (1.1 mol, available from Aldrich) in 1.0 L dichloromethane was added dropwise 108 g chlorotrimethylsilane (1.1 mol). This mixture was allowed to stand at room temperature for three days before 500 mL hexane was added. The mixture was filtered to remove triethylamine hydrochloride, and most of the solvent was removed at reduced pressure. A 200 mL portion of hexane was then added, the mixture filtered again, and solvent removed at reduced pressure to leave the desired product.

후처리

  1. additionwas added
  2. filtrationThe mixture was filtered
  3. customto remove triethylamine hydrochloride
  4. custommost of the solvent was removed at reduced pressure
  5. additionA 200 mL portion of hexane was then added
  6. filtrationthe mixture filtered again
  7. customsolvent removed at reduced pressure

출처 및 근거

ORD 기록
ord-a1acf58fe71c4a9388823d348322928f
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06245922B1

연결된 노트

불러오는 중…