HCID 21196524, 화합물 → HCID 18367302, 화합물
반응식
O[CH:2]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[O:16][CH3:17])[CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][C:4]1=[O:9]>CO.CCOC(C)=O.[Pd].[OH-].[OH-].[Pd+2]>[CH3:17][O:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[CH2:2][CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][C:4]1=[O:9]참가 물질
5
실험 절차
A mixture of 2-[hydroxy-(2-methoxyphenyl)methyl]-cyclohexanone (3.71 g), 10% Pd/C (wet) (1.0 g), and 20% Pd(OH)2/C (180 mg) in MeOH-EtOAc (2:1, 150 ml) was stirred under hydrogen atmosphere at room temperature for 28 hours. The catalyst was removed by filtration and the filtrate was evaporated. The residue was purified by silica gel column chromatography (hexane-EtOAc 7:1) to give 2-(2-methoxybenzyl)cyclohexanone (2.65 g) as an oil.
후처리
- customThe catalyst was removed by filtration
- customthe filtrate was evaporated
- customThe residue was purified by silica gel column chromatography (hexane-EtOAc 7:1)
출처 및 근거
- ORD 기록
- ord-4b64e939b055410a93f6428e070f4e9b
- 출처 데이터셋
- uspto-grants-2001_06
- 특허 번호
- US06245790B1
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