Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → N,N,N',N'-Tetrakis[2-(benzyloxycarbonylamino)-ethyl]-5-nitro-isophthalic acid-diamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 5-Nitroisophthaloyl chloride | HCID 83451 | — |
| 반응물 | N,N''-Di-Z-diethylenetriamine | HCID 4367374 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N,N,N',N'-Tetrakis[2-(benzyloxycarbonylamino)-ethyl]-5-nitro-isophthalic acid-diamide | HCID 17909256 | — |
반응 단계
14.86 g (40 mmol) of the bis[2-(benzyloxycarbonylamino)-ethyl]-amine described in Example 1a and 20.24 g (200 mmol) of triethylamine are dissolved in dimethylformamide and mixed with 4.96 g (20 mmol) of 5-nitro-isophthalic acid dichloride (J. Chem. Soc. 1957, 1172-1175) and stirred overnight at room temperature. The solution is concentrated by evaporation in a vacuum and the residue is chromatographed with ethyl acetate on silica gel.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06248306B1 |
| 출처 데이터셋 | uspto-grants-2001_06 |
| ORD ID | ord-51fe1b4e2e1f42c685f7064504a78e2b |
| 출처 메모 | uspto-grants-2001_06 |