Ammonia → HCID 16658632, 화합물

HRID 1067244

반응식

HRID 1067244 반응식
Cl[S:2]([C:5]1[CH:14]=[C:13]2[C:8]([C:9]([Cl:16])=[CH:10][N:11]=[C:12]2[Cl:15])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[NH3:17]>>[Cl:15][C:12]1[C:13]2[C:8](=[CH:7][CH:6]=[C:5]([S:2](=[O:4])(=[O:3])[NH2:17])[CH:14]=2)[C:9]([Cl:16])=[CH:10][N:11]=1

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 166582941,4-Dichloroisoquinoline-7-sulfonyl chloride

생성물 1

HCID 16658632HCID 16658632, 화합물

실험 절차

7-chlorosulphonyl-1,4-dichloroisoquinoline (110 mg, 0.37 mmol) was dissolved in a solution of saturated methanolic ammonia (NH3) (10 mL) and the solution stirred at room temperature for 1.5 hours. The solvents were evaporated in vacuo and the residue was azeotroped with CH2Cl2 and then partitioned between EtOAc and water. The organic phase was washed with brine, dried (MgSO4) and evaporated in vacuo to give 1,4-dichloro-7-sulphamoylisoquinoline (98 mg, 0.35 mmol) as a white solid.

후처리

  1. customThe solvents were evaporated in vacuo
  2. customthe residue was azeotroped with CH2Cl2
  3. custompartitioned between EtOAc and water
  4. washThe organic phase was washed with brine
  5. dry with materialdried (MgSO4)
  6. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-2cafeccf2f0a4c2499c528193bf31747
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06248738B1

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