Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → N-(4-Chlorobenzyl)-1-methyl-4-oxo-6-(4-thiomorpholinyl-methyl)-1,4-dihydro-3-quinolinecarboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2,4,6-Trimethylpyridine | HCID 7953 | — |
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | N-(4-Chlorobenzyl)-6-(hydroxymethyl)-1-methyl-4-oxo-1,4-dihydro-3-quinolinecarboxamide | HCID 15516933 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-(4-Chlorobenzyl)-1-methyl-4-oxo-6-(4-thiomorpholinyl-methyl)-1,4-dihydro-3-quinolinecarboxamide | HCID 15516934 | 74% |
반응 단계
Methanesulfonyl chloride (0.193 mL) is added to a solution of N-(4-chloro-benzyl)-6-(hydroxymethyl)-1-methyl-4-oxo-1,4-dihydro-3-quinolinecarboxamide (357 mg) from Example No. 2, DMAP (20 mg), and 2,4,6-collidine (0.33 mL) in anhydrous DMF (20 mL). The mixture is stirred at room temperate for 2 h, and poured into water (60 mL). The resulting percipitate is filtered, washed with water (20 mL), and recrystallized from acetonitrile to afford 0.328 g (74%) of the title compound as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06248736B1 |
| 출처 데이터셋 | uspto-grants-2001_06 |
| ORD ID | ord-894f43e873d8468f8926918e183d7075 |
| 출처 메모 | uspto-grants-2001_06 |