Oxalyl chloride → HCID 23445624, 화합물

HRID 1067361노트

반응식

HRID 1067361 반응식
[CH2:1]([C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([CH2:14][CH3:15])[C:11]=1[O:12][CH3:13])[C:6]([OH:8])=O)[CH3:2].C(Cl)(=O)C(Cl)=O.[Sn].[CH2:23]([C:30]1[O:31][C:32]([CH3:36])=[C:33]([CH3:35])[CH:34]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH2:23]([C:30]1[O:31][C:32]([CH3:36])=[C:33]([CH3:35])[C:34]=1[C:6]([C:5]1[CH:9]=[C:10]([CH2:14][CH3:15])[C:11]([O:12][CH3:13])=[C:3]([CH2:1][CH3:2])[CH:4]=1)=[O:8])[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

참가 물질

5

반응물 4

HCID 65578Oxalyl chlorideHCID 5352426Tin atomHCID 15895031HCID 15895031, 화합물HCID 234456633.5-Diethyl-4-methoxybenzoic acid

생성물 1

HCID 23445624HCID 23445624, 화합물

실험 절차

The title compound was prepared according to the procedure in Example 5, step 2, using 3,5-diethyl-4-methoxybenzoic acid (10.66 g, 51.3 mmol), oxalyl chloride (4.90 mL, 56.3 mmol), N,N-DMF (2 drops), tin IV chloride (6.60 mL, 56.3 mmol) and 2-benzyl-4,5-dimethylfuran (11.4 g, 61.3 mmol) to give 22.0 g, of the title compound. 1H NMR δ1.13 (t, 6H), 1.83 (s, 3H), 2.19 (s, 3H), 2.61 (q, 4H), 3.74 (s, 3H), 3.82 (s, 2H), 7.05 (d, 2H), 7.23-7.27 (m, 3H), 7.42 (s, 2H). mass spectrum (EI), m/z 376 (M+).

후처리

  1. customThe title compound was prepared
  2. customto give 22.0 g

출처 및 근거

ORD 기록
ord-c3d08b1ee743495d8db61d4fa1939c14
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06248764B1

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