Bromodiphenylmethane → [(2-Diphenylmethylthio-4,5-dihydronaphtho[1,2-d]thiazol-8-yl)oxy]acetic acid

반응식

C([O:3][C:4](=[O:21])[CH2:5][O:6][C:7]1[CH:20]=[C:19]2[C:10]([CH2:11][CH2:12][C:13]3[S:17][C:16]([SH:18])=[N:15][C:14]=32)=[CH:9][CH:8]=1)C.Br[CH:23]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[C:24]1([CH:23]([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[S:18][C:16]2[S:17][C:13]3[CH2:12][CH2:11][C:10]4[C:19](=[CH:20][C:7]([O:6][CH2:5][C:4]([OH:3])=[O:21])=[CH:8][CH:9]=4)[C:14]=3[N:15]=2)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

참가 물질

반응물 2

HCID 236603Bromodiphenylmethane

HCID 178472936HCID 178472936, 화합물

생성물 1

HCID 18471107[(2-Diphenylmethylthio-4,5-dihydronaphtho[1,2-d]thiazol-8-yl)oxy]acetic acid수율 90%

실험 절차

Using ethyl[(2-mercapto-4,5-dihydronaphtho[1,2-d]thiazol-8-yl)oxy]acetate and bromodiphenylmethane, the procedure of Example 1 was otherwise repeated to synthesize the title compound. Yield 90%.

출처 및 근거

ORD 기록: ord-19a0f217ca434e718c7f69a485c30bf7
출처 데이터셋: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06248766B1

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