Guanidine Hydrochloride → HCID 178478910, 화합물

HRID 1067796

반응식

HRID 1067796 반응식
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([O:13]C)=O)=[CH:8][CH:9]=2)[CH:4]=[CH:3]1.[ClH:15].[NH2:16][C:17]([NH2:19])=[NH:18].C[O-].[Na+]>CO>[ClH:15].[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([NH:18][C:17]([NH2:19])=[NH:16])=[O:13])=[CH:8][CH:9]=2)[CH:4]=[CH:3]1

참가 물질

5

반응물 3

HCID 5742Guanidine HydrochlorideHCID 10679201Methyl 1-methyl-1H-indole-5-carboxylateHCID 10942334Sodium Methoxide

생성물 1

HCID 178478910HCID 178478910, 화합물수율 68.9%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The reaction was carried out in a manner similar to Example 1 except for using 1.00 g (5.29 mmol) of methyl 1-methyl-5-indolecarboxylate, 5.05 g (52.9 mmol) of guanidine hydrochloride and 50 ml of a methanol solution of 2.85 g (52.9 mmol) of sodium methoxide. Thus 0.92 g (68.9%) of 1-methyl-5-indoloylguanidine hydrochloride was obtained.

출처 및 근거

ORD 기록
ord-7ac5db2e75204f30954d940433b71b94
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06248772B1

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