Methanol → HCID 178485129, 화합물

HRID 1067797

반응식

C[N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](C(OC)=O)=[CH:3]1.[ClH:15].[NH2:16][C:17]([NH2:19])=[NH:18].[CH3:20][O-:21].[Na+].[CH3:23]O>>[ClH:15].[CH3:23][NH:18][C:17]([NH:19][C:20]([C:3]1[NH:2][C:10]2[C:5]([CH:4]=1)=[CH:6][CH:7]=[CH:8][CH:9]=2)=[O:21])=[NH:16]

참가 물질

반응물 4

HCID 887Methanol

HCID 5742Guanidine Hydrochloride

HCID 842006Methyl 1-methyl-1H-indole-3-carboxylate

HCID 10942334Sodium Methoxide

생성물 1

HCID 178485129HCID 178485129, 화합물수율 35.9%

실험 절차

The reaction was carried out in a manner similar to Example 1 except for using 1.00 g (5.29 mmol) of methyl 1-methyl-3-indolecarboxylate, 5.05 g (52.9 mmol) of guanidine hydrochloride and 50 ml of a methanol solution of 2.85 g (52.9 mmol) of sodium methoxide. Thus 0.48 g (35.9%) of 1-methyl-3-indoloylguanidine hydrochloride was obtained.

출처 및 근거

ORD 기록: ord-803a8d9310424c359c5510fbafd68d33
출처 데이터셋: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06248772B1

연결된 노트

불러오는 중…