Triethylamine → (2S,9R)-2-[(tert-Butoxycarbonyl)amino]-7-(carbobenzyloxy)-10-chloro-9-hydroxy-7-azadecanoic Acid tert-Butyl Ester
반응식
[C:1]([O:5][C:6](=[O:36])[C@@H:7]([NH:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[CH2:8][CH2:9][CH2:10][CH2:11][N:12]([C:18]([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19])[CH2:13][C@H:14]([OH:17])[CH2:15][Cl:16])([CH3:4])([CH3:3])[CH3:2].C(OC(=O)[C@@H](NC(OC(C)(C)C)=O)CCCCNC[C@@H](O)CCl)(C)(C)C.ClC(OCC1C=CC=CC=1)=O.C(N(CC)CC)C>>[C:1]([O:5][C:6](=[O:36])[C@@H:7]([NH:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[CH2:8][CH2:9][CH2:10][CH2:11][N:12]([C:18]([O:20][CH2:21][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)=[O:19])[CH2:13][C@@H:14]([OH:17])[CH2:15][Cl:16])([CH3:4])([CH3:3])[CH3:2]참가 물질
5
반응물 4
생성물 1
실험 절차
According to the method described for the preparation of 13a, 12b (2.93 g, 7.42 mmol) was reacted with benzyl chloroformate (1.60 g, 9.38 mmol) and triethylamine (1.50 g, 14.81 mmol) to obtain 13b (3.35 g, 85%) as a colorless oil: 1H NMR δ 1.24-1.82 (m, 6H), 1.44 (s, 9H) 1.45 (s, 9H), 3.15-3.64 (m, 6H), 3.92 (m, 1H), 4.00 (m, 1H), 5.12 (m, 2H), 7.25-7.40 (m, 5H); 13C NMR δ 24.0, 28.3, 28.8, 32.5, 42.4, 51.3, 52.3, 55.7, 68.4, 71.0, 71.1, 80.4, 82.5, 129.0, 129.1, 129.6, 138.0, 158.1, 158.4, 173.7; HRMS m/z calcd for C26H42ClN2O7 529.2681, found 529.2691. Anal. calcd. for C26H41ClN2O7: C 59.03, H 7.81, N 5.29. Found: C 58.88, H 7.83, N 5.23. [α]23D−1.7°(c 0.98, CH3OH).
출처 및 근거
- ORD 기록
- ord-a55b3faf10f644658769f49b06cc9689
- 출처 데이터셋
- uspto-grants-2001_06
- 특허 번호
- US06248866B1
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