Potassium Hydroxide → 2-(Piperidin-4-yl)-1,3-benzothiazole

HRID 1068142노트

반응식

HRID 1068142 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH:10]1[CH2:15][CH2:14][N:13](C(=O)C)[CH2:12][CH2:11]1.[OH-].[K+]>CO>[NH:13]1[CH2:12][CH2:11][CH:10]([C:2]2[S:1][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[N:3]=2)[CH2:15][CH2:14]1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 92186951-(4-(Benzo[d]thiazol-2-yl)piperidin-1-yl)ethanone

생성물 1

HCID 14774392-(Piperidin-4-yl)-1,3-benzothiazole수율 46%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 1.4 g of 1-(4-(benzothiazol-2-yl)piperidin-1-yl)ethanone in 10 mL of MeOH was added 7.5 mL of KOH (45 wt. % solution). After refluxing for 18 hours, the reaction was cooled to room temperature. The mixture was partitioned between EtOAc and water. The organic phase was washed with brine and dried over MgSO4. Concentration under reduced pressure gave 540 mg of the title compound as a solid.

후처리

  1. temperatureAfter refluxing for 18 hours
  2. customThe mixture was partitioned between EtOAc and water
  3. washThe organic phase was washed with brine
  4. dry with materialdried over MgSO4
  5. concentrationConcentration under reduced pressure

출처 및 근거

ORD 기록
ord-d0be67bac92b4883aa6f514c01c77427
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06248755B1

반응 노트

불러오는 중…