Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl alpha-benzylacetoacetate → 1-benzyl-4-(4-benzyl-5-methyl-1H-pyrazol-3(2H)-on-2-yl)-piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl alpha-benzylacetoacetate | HCID 246929 | — |
| 반응물 | 1-Benzyl-4-hydrazinylpiperidine | HCID 416192 | — |
| 생성물 | 1-benzyl-4-(4-benzyl-5-methyl-1H-pyrazol-3(2H)-on-2-yl)-piperidine | HCID 21192948 | 60.2% |
반응 단계
A mixture of 1.52 g 1-benzyl-4-hydrazinopiperidine and 2.0 g of ethyl 2-benzylacetoacetate in 20 mL of xylenes was refluxed for 1 hour. The solvent was removed under reduced pressure and the residue purified by silica gel chromatography (300 mL column). Elution with 0-5% MeOH in dichloromethane gave 1.61 g of product, 1-benzyl-4-(4-benzyl-5-methyl-1H-pyrazol-3(2H)-on-2-yl)-piperidine. ESI-MS 362.2 (M+H); HPLC A: 2.05 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06248755B1 |
| 출처 데이터셋 | uspto-grants-2001_06 |
| ORD ID | ord-109330f3531f456e93b4468b45f65646 |
| 출처 메모 | uspto-grants-2001_06 |