Ethyl 1-phenylpiperidine-4-carboxylate → 1-Phenylpiperidine-4-carbaldehyde

HRID 1068428노트

반응식

HRID 1068428 반응식
[C:1]([CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)(OCC)=[O:2].[H-].C([Al+]CC(C)C)C(C)C>C1COCC1.C1(C)C=CC=CC=1>[CH:1]([CH:6]1[CH2:7][CH2:8][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:10][CH2:11]1)=[O:2]

참가 물질

5

반응물 2

HCID 6470Ethyl 1-phenylpiperidine-4-carboxylateHCID 21225700Diisobutylaluminumhydride

생성물 1

HCID 138429921-Phenylpiperidine-4-carbaldehyde

시약·촉매·용매 2

HCID 1140Toluene용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
-78 °C

실험 절차

The product from Example 28, Step C is dissolved in THF and cooled to −78° C. under nitrogen. A solution of diisobutylaluminum hydride (1 eq.) in toluene is added dropwise. After 30 min, the reaction is quenched with saturated sodium potassium tartrate solution. The mixture is extracted with ethyl acetate, and the organic phase washed with saturated brine, and dried over MgSO4. Filtration and concentration provides the title compound

후처리

  1. customthe reaction is quenched with saturated sodium potassium tartrate solution
  2. extractionThe mixture is extracted with ethyl acetate
  3. washthe organic phase washed with saturated brine
  4. dry with materialdried over MgSO4
  5. filtrationFiltration and concentration

출처 및 근거

ORD 기록
ord-4c33572b981449f3a3679a6c3c1f1327
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06248756B1

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