Nitric Acid → 1-Bromo-2,5-dichloro-4-nitrobenzene

HRID 1068605

반응식

HRID 1068605 반응식
[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[Cl:9].[N+:10]([O-])([OH:12])=[O:11]>>[Cl:9][C:3]1[CH:4]=[C:5]([N+:10]([O-:12])=[O:11])[C:6]([Cl:8])=[CH:7][C:2]=1[Br:1]

참가 물질

3

반응물 2

HCID 944Nitric AcidHCID 150332-Bromo-1,4-dichlorobenzene

생성물 1

HCID 211900161-Bromo-2,5-dichloro-4-nitrobenzene

실험 절차

A solution of 2-bromo-1,4-dichlorobenzene (1.000 g, 4.443 mmol, Aldrich, used as received) in fuming HNO3 (7.0 mL) was stirred at 50° C. for 1.5 h and poured into ice (80 g). Yellowish white solid was filtered, washed with water (10 mL), and dried under vacuum to obtain 1.14 g (95%) of pure (CH NMR) title compound as a yellowish white powder; m.p. 50-53° C. (lit m.p. 57-58° C.; Fox, D. L. and Turner, E. E., J. Chem. Soc. 1859 (1930)); 1H NMR (CDCl3): δ 7.863 (s, 1H), 8.030 (s, 1H). This material was used as such for the next reaction.

후처리

  1. filtrationYellowish white solid was filtered
  2. washwashed with water (10 mL)
  3. customdried under vacuum

출처 및 근거

ORD 기록
ord-4d74f826a7da43e5ab2804fc6036a716
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06251903B1

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