4-Thiazolidinone, 3-methyl-2-thioxo- → 5-[[4-[(4-Acetyl-3-hydroxy-2-propylphenyl)methoxy]phenyl]methylene]-3-methyl-2-thioxo-4-thiazolidinone

HRID 1069120

반응식

HRID 1069120 반응식
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][O:11][C:12]2[CH:19]=[CH:18][C:15]([CH:16]=O)=[CH:14][CH:13]=2)=[C:6]([CH2:20][CH2:21][CH3:22])[C:5]=1[OH:23])(=[O:3])[CH3:2].C([O-])(=O)C.[Na+].[CH3:29][N:30]1[C:34](=[O:35])[CH2:33][S:32][C:31]1=[S:36]>C(O)(=O)C>[C:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][O:11][C:12]2[CH:19]=[CH:18][C:15]([CH:16]=[C:33]3[S:32][C:31](=[S:36])[N:30]([CH3:29])[C:34]3=[O:35])=[CH:14][CH:13]=2)=[C:6]([CH2:20][CH2:21][CH3:22])[C:5]=1[OH:23])(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 729004-Thiazolidinone, 3-methyl-2-thioxo-HCID 517045Sodium AcetateHCID 211912774-[(4-Acetyl-3-hydroxy-2-propylphenyl)methoxy]benzaldehyde

생성물 1

HCID 867525075-[[4-[(4-Acetyl-3-hydroxy-2-propylphenyl)methoxy]phenyl]methylene]-3-methyl-2-thioxo-4-thiazolidinone

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
100 °C

실험 절차

Under a nitrogen atmosphere in a three-neck round bottom flask 4-[(4-acetyl-3-hydroxy-2-propylphenyl)methoxy]benzaldehyde (90.0 mg, 0.29 mmol) was dissolved in acetic acid (1.5 ml) with stirring. To this solution was added sodium acetate (82.8 mg, 1.00 mmol) and N-methylrhodanine (42.5 mg, 0.29 mmol). The reaction mixture was then heated to 100° C. and maintained at this temperature for about two hours at which time the reaction mixture was raised to the reflux temperature and allowed to reflux for about 28 hours. The reaction progress was monitored by thin layer chromatography.

후처리

  1. temperaturemaintained at this temperature for about two hours at which time the reaction mixture
  2. temperaturewas raised to the reflux temperature
  3. temperatureto reflux for about 28 hours

출처 및 근거

ORD 기록
ord-03a655ea75a4460ca91808761dd55d17
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06251928B1

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