2-Bromoethanol → 2-{[(1R)-1-phenylethyl]amino}ethan-1-ol

HRID 1069402노트

반응식

HRID 1069402 반응식
[CH3:1][C@@H:2]([NH2:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Br[CH2:11][CH2:12][OH:13]>ClCCl>[OH:13][CH2:12][CH2:11][NH:9][C@H:2]([CH3:1])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 108982-BromoethanolHCID 6431891-Phenethylamine, (+)-

생성물 1

HCID 69938212-{[(1R)-1-phenylethyl]amino}ethan-1-ol수율 76,003%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
51 °C

실험 절차

51.45 g (0.43 mmole) of (R)-(+)-α-methylbenzylamine was dissolved in 52 ml of dichloromethane and 63.78 g (0.51 mmole) of 2-bromoethanol was added thereto. This mixture was stirred at 51° C. for 50 hours to complete the reaction. The reaction solution was concentrated under reduced pressure and the residue was subjected to fractional distillation to obtain 54 g of the title compound having pale yellow color.

후처리

  1. customthe reaction
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. distillationthe residue was subjected to fractional distillation

출처 및 근거

ORD 기록
ord-f52640b0735f4828a029802ddd5ff12a
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06252076B1

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