Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Iodooctane → 5-methoxy-2-methyl-1-octyl-1H-indole-3-acetic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Iodooctane | HCID 12380 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Ethyl (5-methoxy-2-methyl-1H-indol-3-yl)acetate | HCID 10729163 | — |
| 생성물 | 5-methoxy-2-methyl-1-octyl-1H-indole-3-acetic acid ethyl ester | HCID 53772942 | 51.5% |
반응 단계
Using the procedure described in Example 50, Part A, 2.47 g (0.01 mol) of 5-methoxy-2-methyl-1H-indole-3-acetic acid ethyl ester was reacted with 0.48 g (0.012 mol) of 60% NaH/mineral oil and then 2.17 mL (0.012 mol of iodooctane. The product was chromatographed on silica gel and eluted with 5% EtOAc/toluene to give 1.85 g (51% yield) of 5-methoxy-2-methyl-1-octyl-1H-indole-3-acetic acid ethyl ester as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06252084B1 |
| 출처 데이터셋 | uspto-grants-2001_06 |
| ORD ID | ord-a0b2dd99105f4b3f893c474cfc89ab4b |
| 출처 메모 | uspto-grants-2001_06 |