Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-(5-Methyl-2-phenyl-4-oxazolylmethoxy)benzyl alcohol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | 4-(5-Methyl-2-phenyl-4-oxazolyl)methoxybenzaldehyde | HCID 10756116 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-(5-Methyl-2-phenyl-4-oxazolylmethoxy)benzyl alcohol | HCID 11022807 | 98% |
반응 단계
To a solution of 4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzaldehyde (33.42 g) in methanol (150 ml)-tetrahydrofurane (30 ml), sodium borohydride (4.31 g) was added in portions at 0° C. After stirring for 30 minutes at room temperature, water was added to the reaction mixture, and the mixture was stirred for 1 hour. The crystals of 4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzylalcohol (32.85 g, yield 98%) was isolated by filtration. Recrystallization from ethyl acetate-diethylether gave pale-yellow crystals. m.p. 128-129° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06251926B1 |
| 출처 데이터셋 | uspto-grants-2001_06 |
| ORD ID | ord-1d661388d0c94aa68bdaede1a636c8e3 |
| 출처 메모 | uspto-grants-2001_06 |