Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 4-[2-(1-Pyrrolidinyl)ethoxy]phenyl 2-[6-[2-(1-Pyrrolidinyl)ethoxy]pyrid-3-yl]benzo[b]-thiophen-3-yl Ketone Dioxalate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 4-(2-Pyrrolidin-1-ylethoxy)benzoic acid hydrochloride | HCID 13174868 | — |
| 반응물 | 5-(Benzo[b]thiophen-2-yl)pyrid-2-yl 2-(1-pyrrolidinyl)ethyl ether | HCID 21182907 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 4-[2-(1-Pyrrolidinyl)ethoxy]phenyl 2-[6-[2-(1-Pyrrolidinyl)ethoxy]pyrid-3-yl]benzo[b]-thiophen-3-yl Ketone Dioxalate | HCID 86757082 | 30% |
반응 단계
By essentially following the procedure detailed in Example 1, Part C, the title compound was prepared from 5-(benzo[b]thiophen-2-yl)pyrid-2-yl 2-(1-pyrrolidinyl)ethyl ether (Part B) and 4-[2-(1-pyrrolidinyl)-ethoxy]benzoic acid hydrochloride in 30% yield as a solid following flash chromatography (SiO2; 5% MeOH in CHCl3). The free base was converted to the dioxalate salt according to the conditions outlined in Example 1, Part C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06251921B1 |
| 출처 데이터셋 | uspto-grants-2001_06 |
| ORD ID | ord-331901968ac54baba43645a7fb209b5d |
| 출처 메모 | uspto-grants-2001_06 |