Pivalaldehyde → HCID 21182945, 화합물

HRID 1070353

반응식

HRID 1070353 반응식
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:33]=[CH:32][C:12]([CH2:13][C:14]3[C:15]4[CH:31]=[CH:30][CH:29]=[CH:28][C:16]=4[S:17][C:18]=3[C:19]3[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][NH2:27])=[CH:21][CH:20]=3)=[CH:11][CH:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:34][C:35]([CH3:39])(C)[CH:36]=O.[C:40](O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>ClCCl>[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:33]=[CH:32][C:12]([CH2:13][C:14]3[C:15]4[CH:31]=[CH:30][CH:29]=[CH:28][C:16]=4[S:17][C:18]=3[C:19]3[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][NH:27][CH2:40][CH2:36][CH:35]([CH3:39])[CH3:34])=[CH:21][CH:20]=3)=[CH:11][CH:10]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

참가 물질

5

반응물 3

HCID 12417PivalaldehydeHCID 5049666Sodium triacetoxyborohydrideHCID 224627162-[4-(2-Aminoethyl)phenyl]-3-[4-[2-(1-pyrrolidinyl)ethoxy]benzyl]benzo[b]thiophene

생성물 1

HCID 21182945HCID 21182945, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3-[4-[2-(1-Pyrrolidinyl)ethoxy]benzyl]-2-[4-(2-aminoethyl)phenyl]benzo[b]thiophene (75 mg) was dissolved in dichloromethane (3.0 mL), treated with trimethylacetaldehyde (30 μL) and sodium triacetoxyborohydride (56 mg) sequentially and allowed to stir at ambient temperature for 3 h. The reaction mixture was concentrated, and column chromatography with Et3N:EtOAc (0-5%) afforded the product (55 mg).

후처리

  1. concentrationThe reaction mixture was concentrated

출처 및 근거

ORD 기록
ord-b8247bb70cab41d1b4ac24bca3b82a2e
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06251921B1

연결된 노트

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