Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Furan → (3,5-Dioxo-10-oxa-4-azatricyclo[5.2.1.02,6]dec-4-yl)acetonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Furan | HCID 8029 | — |
| 반응물 | Maleimide | HCID 10935 | — |
| 반응물 | Bromoacetonitrile | HCID 11534 | — |
| 반응물 | 10-Oxa-4-azatricyclo(5.2.1.02,6)decane-3,5-dione | HCID 239727 | — |
| 용매 | Acetone | HCID 180 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (3,5-Dioxo-10-oxa-4-azatricyclo[5.2.1.02,6]dec-4-yl)acetonitrile | HCID 22396537 | — |
반응 단계
Synthesis took place in analogy to Example VI a from 10-oxa-4-azatricyclo[5.2.1.02,6]decane-3,5-dione (obtainable from maleimide and furan from Diels-Alder reaction for example as described by Padwa, A.; Dimitroff, M.; Waterson, A. G.; Wu, T.; J Org Chem 1997, 62, 4088-4096 and subsequent hydrogenation as described by Ansell, M. F.; Caton, M. P. L.; North, P. C.; Tetrahedron Lett. 1982, 23, 2811) and bromoacetonitrile with the exception that acetone was used as solvent in place of DMF. The substance was employed as crude product in the next reaction.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06903089B1 |
| 출처 데이터셋 | uspto-grants-2005_06 |
| ORD ID | ord-5397b9d01bdc473a8cd5f7b98554a071 |
| 출처 메모 | uspto-grants-2005_06 |