3,4-Dichlorobenzyl chloride → 3,4-dichlorobenzyl-4-piperidone

HRID 1070488노트

반응식

HRID 1070488 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5]Cl.O.Cl.[O:13]=[C:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.C(N(CC)CC)C>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5][N:17]1[CH2:18][CH2:19][C:14](=[O:13])[CH2:15][CH2:16]1

참가 물질

5

반응물 3

HCID 76093,4-Dichlorobenzyl chlorideHCID 8471TriethylamineHCID 2723901Piperonylamine

생성물 1

HCID 108487763,4-dichlorobenzyl-4-piperidone

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 3,4-dichlorobenzyl chloride (2.8 ml), 4-ketopiperidine hydrochloride monohydrate and triethylamine (8 ml) in dimethylformamide (30 ml) was stirred at room temperature for 20 h. The mixture was partitioned between water and ethyl acetate, the organic layer dried and evaporated under reduced pressure. Purification was by chromatography eluting with 40-50% ethyl acetate/isohexane. Yield 2.1 g.

후처리

  1. customThe mixture was partitioned between water and ethyl acetate
  2. customthe organic layer dried
  3. customevaporated under reduced pressure
  4. customPurification
  5. washeluting with 40-50% ethyl acetate/isohexane

출처 및 근거

ORD 기록
ord-659355a251114a28b73fe0c6bc1705bb
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06903085B1

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