N-BOC-ethylenediamine → HCID 22396192, 화합물

HRID 1070489노트

반응식

HRID 1070489 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1[Cl:16])[CH2:5][N:6]1[CH2:11][CH2:10][C:9](=O)[CH2:8][CH2:7]1.[C:17]([O:21][C:22]([NH:24][CH2:25][CH2:26][NH2:27])=[O:23])([CH3:20])([CH3:19])[CH3:18].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>ClCCl>[C:17]([O:21][C:22](=[O:23])[NH:24][CH2:25][CH2:26][NH:27][CH:9]1[CH2:10][CH2:11][N:6]([CH2:5][C:4]2[CH:13]=[CH:14][C:15]([Cl:16])=[C:2]([Cl:1])[CH:3]=2)[CH2:7][CH2:8]1)([CH3:20])([CH3:18])[CH3:19]

참가 물질

5

반응물 3

HCID 187201N-BOC-ethylenediamineHCID 5049666Sodium triacetoxyborohydrideHCID 108487763,4-dichlorobenzyl-4-piperidone

생성물 1

HCID 22396192HCID 22396192, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of the product from step (i) (1.61 g), N-(tert-butoxycarbonyl)-ethylenediamine (1 g) and sodium triacetoxyborohydride (2.12 g) in dichloromethane (20 ml) was stirred at room temperature for 3 h. The mixture was partitioned between water and ethyl acetate, the organic layer dried and evaporated under reduced pressure. Yield 1.28 g.

후처리

  1. customThe mixture was partitioned between water and ethyl acetate
  2. customthe organic layer dried
  3. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-580f275b589746b4bc43ed6206780079
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06903085B1

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