참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 6-Methoxy-isoquinoline 2-oxide hydrochloride | HCID 22397332 | — |
| 용매 | Phosphorus oxychloride | HCID 24813 | — |
| 생성물 | 1-Chloro-6-methoxyisoquinoline | HCID 21901074 | — |
반응 단계
6-Methoxy-isoquinoline-N-oxide hydrochloride (1a, 85 g; 400 mmol) was carefully added in portions to phosphoryl chloride (550 mL) at a temperature of 90° C., after which the mixture was stirred for 6 h at 90° C. Excess of phosphoryl chloride was removed in vacuo. The remaining white solid was washed with water, filtered and dried in vacua. Yield: 68 g (88%); white solid; m.p. 72-74° C.; El-MS: 193 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06903107B1 |
|---|
| 출처 데이터셋 | uspto-grants-2005_06 |
|---|
| ORD ID | ord-f65656e336f847d098a261866c2b097a |
|---|
| 출처 메모 | uspto-grants-2005_06 |
|---|
