Ethanol → 4-(Oxazol-4-yl)aniline

HRID 1070830노트

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HRID 1070830 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[CH:12][O:13][CH:14]=2)=[CH:6][CH:5]=1)([O-])=O.C(O)C.[H][H]>[C].[Pd].O1CCCC1>[O:13]1[CH:14]=[C:10]([C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=2)[N:11]=[CH:12]1

참가 물질

6

반응물 3

HCID 702EthanolHCID 145677974-(4-Nitrophenyl)oxazoleHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 223978534-(Oxazol-4-yl)aniline

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

5% Palladium-carbon powder was added to a suspension of 4-(4-nitrophenyl)-1,3-oxazole in mixture of ethanol and tetrahydrofuran, and the reaction mixture was stirred under 1 atm of hydrogen at ambient temperature for 12 hours. The reaction mixture was filtered through Celite, and the resulting filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography, to obtain [4-(1,3-oxazol-4-yl)phenyl]amine (pale yellow solid). Electron Impact-MS (M)+:160.

후처리

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationthe resulting filtrate was concentrated under reduced pressure
  3. customThe resulting crude product was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-95af47684b0e4769aaa2c925c5fec751
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06903125B2

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