참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Iodopropane | HCID 33643 | — |
| 반응물 | Dicyclohexano-18-crown-6 | HCID 85955 | — |
| 반응물 | Potassium Bicarbonate | HCID 516893 | — |
| 반응물 | HCID 178500329 | HCID 178500329 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 10223420 | HCID 10223420 | — |
반응 단계
100 mg of 6-[[2-mercapto-1-phenyl-1H-benzimidazol-6-yl]oxy]hexanoic acid methyl ester was dissolved in 2 ml of N,N-dimethylformamide, mixed with 40 μl of propyl iodide, 57 mg of potassium hydrogen carbonate and 10 mg of dicyclohexano-18-crown-6, and the mixture was stirred for 15 hours at 20° C. It was filtered, and the filtrate was concentrated by evaporation in a vacuum. The residue was purified by column chromatography on silica gel. 103 mg was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06903126B2 |
|---|
| 출처 데이터셋 | uspto-grants-2005_06 |
|---|
| ORD ID | ord-b81001596faa4bf7aebe0747d7f86893 |
|---|
| 출처 메모 | uspto-grants-2005_06 |
|---|
