Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1070852생성일: 2026년 10월 26일
Benzyl Bromide → 6-[[2-Benzylmercapto-1-(4-methylphenyl)-1H-benzimidazol-6-yl]oxy]Hexanoic Acid Methyl Ester
https://huagongshe.com/reaction/1070852
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Dicyclohexano-18-crown-6 | HCID 85955 | — |
| 반응물 | Potassium Bicarbonate | HCID 516893 | — |
| 반응물 | HCID 178500330 | HCID 178500330 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 6-[[2-Benzylmercapto-1-(4-methylphenyl)-1H-benzimidazol-6-yl]oxy]Hexanoic Acid Methyl Ester | HCID 10162512 | — |
반응 단계
800 mg of 6-[[2-mercapto-1-(4-methylphenyl)-1H-benzimidazol-6-yl]oxy]hexanoic acid methyl ester was dissolved in 8 ml of N,N-dimethylformamide, mixed with 0.3 ml of benzylbromide, 438 mg of potassium hydrogen carbonate and 75 mg of dicyclohexano-18-crown-6, and the mixture was stirred for 15 hours at 20° C. It was filtered, and the filtrate was concentrated by evaporation in a vacuum. The residue was purified by column chromatography on silica gel. 976 mg was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06903126B2 |
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| 출처 데이터셋 | uspto-grants-2005_06 |
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| ORD ID | ord-2118528183b0490796652adc28040645 |
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| 출처 메모 | uspto-grants-2005_06 |
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