HCID 69462252, 화합물 → HCID 10287430, 화합물

HRID 1070907노트

반응식

HRID 1070907 반응식
[N:1]12[CH2:24][CH2:23][CH2:22][C@@H:21]1[C:20](=[O:25])[O:19][CH2:18][CH:17]=[CH:16][CH2:15][O:14][C:13](=[O:26])[C@@H:12]1[N:8]([CH2:9][CH2:10][CH2:11]1)[C:7](=[O:27])[CH2:6][CH2:5][CH2:4][CH2:3][C:2]2=[O:28]>C(OC(=O)C)C.[Pd]>[N:1]12[CH2:24][CH2:23][CH2:22][C@@H:21]1[C:20](=[O:25])[O:19][CH2:18][CH2:17][CH2:16][CH2:15][O:14][C:13](=[O:26])[C@@H:12]1[N:8]([CH2:9][CH2:10][CH2:11]1)[C:7](=[O:27])[CH2:6][CH2:5][CH2:4][CH2:3][C:2]2=[O:28]

참가 물질

4

반응물 1

HCID 69462252HCID 69462252, 화합물

생성물 1

HCID 10287430HCID 10287430, 화합물수율 98%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 260 mg (0.66 mmol) (12R,21R)-14,19-dioxa-1,8-diaza-tricyclo[19.3.0.0 8,12]tetracos-16-ene-2,7,13,20-tetraone and 30 mg 10% palladium/carbon in 10 ml ethylacetate was hydrogenated over night. Filtration and removal of the solvent yielded 255 mg (98%) (12R,21R)-14,19-dioxa-1,8-diaza-tricyclo[19.3.0.0 8,12]tetracosane-2,7,13,20-tetraone as a light yellow oil, MS m/e (%): 395 (M+H+, 100).

후처리

  1. waitwas hydrogenated over night
  2. filtrationFiltration and removal of the solvent

출처 및 근거

ORD 기록
ord-94b603eebe4d4467b53bb2489a7f32c9
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06903129B2

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