HCID 69461265, 화합물 → HCID 10287892, 화합물

HRID 1070908노트

반응식

HRID 1070908 반응식
[N:1]12[CH2:26][CH2:25][CH2:24][C@@H:23]1[C:22](=[O:27])[O:21][CH2:20][CH2:19][CH:18]=[CH:17][CH2:16][CH2:15][O:14][C:13](=[O:28])[C@@H:12]1[N:8]([CH2:9][CH2:10][CH2:11]1)[C:7](=[O:29])[CH2:6][CH2:5][CH2:4][CH2:3][C:2]2=[O:30]>C(OC(=O)C)C.[Pd]>[N:1]12[CH2:26][CH2:25][CH2:24][C@@H:23]1[C:22](=[O:27])[O:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][O:14][C:13](=[O:28])[C@@H:12]1[N:8]([CH2:9][CH2:10][CH2:11]1)[C:7](=[O:29])[CH2:6][CH2:5][CH2:4][CH2:3][C:2]2=[O:30]

참가 물질

4

반응물 1

HCID 69461265HCID 69461265, 화합물

생성물 1

HCID 10287892HCID 10287892, 화합물수율 79%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 150 mg (0.36 mmol) (12R,23R)-14,21-dioxa-1,8-diaza-tricyclo[21.3.0.0 8,12]hexacos-17-ene-2,7,13,22-tetraone and 20 mg 10%) palladium/carbon in 5 ml ethylacetate was hydrogenated over night. Filtration and removal of the solvent yielded 120 mg (79%) (12R,23R)-14,21-dioxa-1,8-diaza-tricyclo[21.3.0.0 8,12]hexacosane-2,7,13,22-tetraone as a light yellow oil, MS m/e (%): 423 (M+H+, 100).

후처리

  1. waitwas hydrogenated over night
  2. filtrationFiltration and removal of the solvent

출처 및 근거

ORD 기록
ord-e5c776758ad04a32b038afe787ba4c8f
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06903129B2

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