Dichloromethane → Tert-butyl 4-[(3,4-dichlorophenyl)sulfonyl]piperidine-1-carboxylate

HRID 1070919노트

반응식

HRID 1070919 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11](SC2C=CC(Cl)=C(Cl)C=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26](C(OO)=O)[CH:25]=1.[S:34](S([O-])=O)([O-:37])(=O)=[O:35].[Na+].[Na+].[Cl:43]CCl>O>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([S:34]([C:26]2[CH:27]=[CH:28][C:29]([Cl:43])=[C:24]([Cl:23])[CH:25]=2)(=[O:37])=[O:35])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

6

반응물 4

HCID 6344DichloromethaneHCID 70297m-Chloroperbenzoic acidHCID 656671Sodium PyrosulfiteHCID 685523534-(3,4-Dichloro-phenylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 68550800Tert-butyl 4-[(3,4-dichlorophenyl)sulfonyl]piperidine-1-carboxylate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The product from Step 1 (1 g) and m-chloroperbenzoic acid (1.19 g) were stirred at ambient temperature in dichloromethane (10 ml) for 18 hours. Sodium metabisulphite (1.19 g) in water (5 ml) was added and stirring was continued for 0.5 hours after which the reaction mixture was extracted with dichloromethane. The combined organics were washed with saturated sodium bicarbonate solution, dried (MgSO4) and evaporated to give the sub-title compound (0.34 g).

후처리

  1. extractionafter which the reaction mixture was extracted with dichloromethane
  2. washThe combined organics were washed with saturated sodium bicarbonate solution
  3. dry with materialdried (MgSO4)
  4. customevaporated

출처 및 근거

ORD 기록
ord-9c53538a6e464e6dae98fe4d0bd5dbe9
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06903115B2

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