4-Azido-2-methyl-pyrrolidine-1-carboxylic Acid T-butyl Ester → Tert-butyl 4-amino-2-methylpyrrolidine-1-carboxylate

HRID 1071504노트

반응식

HRID 1071504 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH:11]([N:13]=[N+]=[N-])[CH2:10][CH:9]1[CH3:16])=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(OCC)(=O)C>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH:11]([NH2:13])[CH2:10][CH:9]1[CH3:16])=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 1

HCID 140411954-Azido-2-methyl-pyrrolidine-1-carboxylic Acid T-butyl Ester

생성물 1

HCID 19354295Tert-butyl 4-amino-2-methylpyrrolidine-1-carboxylate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

The 4-azido-2-methyl-pyrrolidine-1-carboxylic acid t-butyl ester (93.41 mg, 0.41 mmol) was taken up in ethyl acetate in a Paar vessel. The solution was flushed with argon and Pd/C (100.00 mg) was added to the vessel. The argon atmosphere was replaced by hydrogen at 50 psi. The vessel was shaken for 12 h. The hydrogen atmosphere was replaced by argon and the solution was filtered through a celite pad. The pad was washed twice with ethyl acetate. The solvent was removed under reduced pressure. The product was used without further purification. Yield 79.65 mg.C10H20N2O2 MS m/e=200.2 (M+).

후처리

  1. customThe solution was flushed with argon and Pd/C (100.00 mg)
  2. additionwas added to the vessel
  3. filtrationthe solution was filtered through a celite pad
  4. washThe pad was washed twice with ethyl acetate
  5. customThe solvent was removed under reduced pressure
  6. customThe product was used without further purification

출처 및 근거

ORD 기록
ord-231ae6658a604b9f90cf14b9f043ea05
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06906067B2

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