HCID 22393544, 화합물 → HCID 22393533, 화합물
반응식
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[N+:11]([O-])=O)[C:7](=[O:14])[NH:6][CH2:5]2>C(OCC)(=O)C>[NH2:11][C:10]1[CH:9]=[C:8]2[C:4]([CH2:5][NH:6][C:7]2=[O:14])=[CH:3][C:2]=1[CH3:1]참가 물질
3
실험 절차
5-Methyl-6-nitro-2,3-dihydro-isoindol-1-one (100.00 mg, 0.52 mmol) was taken up in ethyl acetate in a Paar vessel and flushed with argon. Palladium on carbon (25 mg) was added and the argon atmosphere was replaced with hydrogen at 50 psi. The vessel was shaken for 12 h. The hydrogen was then replaced with argon and the catalyst was removed by filtration through celite. The solvent was removed under reduced pressure to yield 65.8 mg of the desired amine. C9H10N2O MS m/e=163.2 (M+H).
후처리
- customflushed with argon
- additionPalladium on carbon (25 mg) was added
- customthe catalyst was removed by filtration through celite
- customThe solvent was removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-cc4fa0ef5f1744418518e2d38bfd1209
- 출처 데이터셋
- uspto-grants-2005_06
- 특허 번호
- US06906067B2
반응 노트
불러오는 중…