2-(Chloromethyl)aniline hydrochloride → 2-[[(5,6-Dimethyl-1H-benzimidazol-2-yl)thio]methyl]benzenamine

HRID 1071534노트

반응식

HRID 1071534 반응식
[CH3:1][C:2]1[C:11]([CH3:12])=[CH:10][C:5]2[N:6]=[C:7]([SH:9])[NH:8][C:4]=2[CH:3]=1.Cl.Cl[CH2:15][C:16]1[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=1[NH2:18]>>[CH3:12][C:11]1[C:2]([CH3:1])=[CH:3][C:4]2[NH:8][C:7]([S:9][CH2:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[NH2:18])=[N:6][C:5]=2[CH:10]=1

참가 물질

3

반응물 2

HCID 123879412-(Chloromethyl)aniline hydrochlorideHCID 178422342HCID 178422342, 화합물

생성물 1

HCID 137541362-[[(5,6-Dimethyl-1H-benzimidazol-2-yl)thio]methyl]benzenamine

실험 절차

The title compound was prepared by the method of Example 1 using 2.56 g of 5,6-dimethyl-2-mercaptobenzimidazole instead of 2-mercaptobenzimidazole and 2.56 g of 2-(chloromethyl) aniline hydrochloride instead of 2-(chloromethyl)-N,N-dimethylaniline. Instead of using sodium carbonate in an extraction, the crude precipitate was neutralized with triethylamine in methanol. Trituration of the resultant crude title compound with methanol and diethyl ether gave 2.0 g of analytically pure title compound. Analysis. Calc'd. for C15H15N3S: C, 67.81; H, 6.05; N,14.83; S, 11.31. Found: C, 67.21; H, 6.16; N, 14.50; S, 11.06.

후처리

  1. extractionInstead of using sodium carbonate in an extraction

출처 및 근거

ORD 기록
ord-c2ad029856124bdbbcd4aa8131cc1fb6
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06906078B2

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