Methyl 2-(bromomethyl)-3-phenylacrylate → (E)-2-Formyloxymethyl-3-phenylacrylic acid methyl ester
반응식
[CH:1]([O-:3])=[O:2].C([NH+](CC)CC)C.[CH3:11][O:12][C:13](=[O:24])/[C:14](/[CH2:22]Br)=[CH:15]/[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(#N)C>[CH3:11][O:12][C:13](=[O:24])/[C:14](/[CH2:22][O:3][CH:1]=[O:2])=[CH:15]/[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1참가 물질
4
실험 절차
To a stirred solution of triethylammonium formate (1.87 g) in acetonitrile (4 ml) was added (Z)-2-bromomethyl-3-phenylacrylic acid methyl ester (1.30 g) and the mixture heated at reflux for 2 hours. The reaction was cooled and extracted into diethyl ether (3×10 ml). The combined organics were dried (MgSO4) and concentrated under reduced pressure to afford the title compound as a crude oil.
후처리
- temperaturethe mixture heated
- temperatureat reflux for 2 hours
- temperatureThe reaction was cooled
- extractionextracted into diethyl ether (3×10 ml)
- dry with materialThe combined organics were dried (MgSO4)
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-a7d56f59ddeb45fbaac69457384e656a
- 출처 데이터셋
- uspto-grants-2005_06
- 특허 번호
- US06906085B2
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