Potassium Hydroxide → 1,3-Diphenyl-2-propyn-1-one

HRID 1071760

반응식

HRID 1071760 반응식
[OH-].[K+].[CH:3]1[CH:8]=[CH:7][C:6](/[CH:9]=[C:10](\Br)/[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:12])=[CH:5][CH:4]=1>O.O.CC(C)=O>[CH:3]1[CH:8]=[CH:7][C:6]([C:9]#[C:10][C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:12])=[CH:5][CH:4]=1

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 5383396alpha-Bromochalcone

생성물 1

HCID 976371,3-Diphenyl-2-propyn-1-one

시약·촉매·용매 2

HCID 962Water용매2회HCID 18366337Propan-2-one--water (1/1)용매

실험 절차

Potassium hydroxide (3.48 mmol), dissolved in water (0.87 M (4.0 ml)), is added over about 30 minutes to a refluxing solution of the alpha-bromochalcone (3.48 mmol) in 0.35 M of 1:1 water/acetone (5 ml each). After 20 minutes of further refluxing, the solution is cooled and diluted with water. The water is extracted with ether, which is dried with MgSO4 and evaporated. Chromatography on silica gel yielded 1,3-diphenylpropynone and its derivatives. VI. alpha-Tetralonylideneacetophenone Derivatives

후처리

  1. temperaturethe solution is cooled
  2. extractionThe water is extracted with ether, which
  3. dry with materialis dried with MgSO4
  4. customevaporated

출처 및 근거

ORD 기록
ord-91892963b0684dd5907003560b829306
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06906105B2

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