N-[2-(dimethylamino)ethyl]-6-nitro-1H-indole-2-carboxamide → 6-Amino-1H-indole-2-carboxylic acid (2-dimethylamino-ethyl)-amide

HRID 1071811노트

반응식

HRID 1071811 반응식
[CH3:1][N:2]([CH3:20])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[NH:9][C:10]2[C:15]([CH:16]=1)=[CH:14][CH:13]=[C:12]([N+:17]([O-])=O)[CH:11]=2)=[O:7]>C(O)C.C(OC(=O)C)C.[Pd]>[CH3:1][N:2]([CH3:20])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[NH:9][C:10]2[C:15]([CH:16]=1)=[CH:14][CH:13]=[C:12]([NH2:17])[CH:11]=2)=[O:7]

참가 물질

4

반응물 1

HCID 85801420N-[2-(dimethylamino)ethyl]-6-nitro-1H-indole-2-carboxamide

생성물 1

HCID 867597646-Amino-1H-indole-2-carboxylic acid (2-dimethylamino-ethyl)-amide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 21584252Ethanol ethylacetate용매

실험 절차

To a solution of 82.9 mg (0.3 mmole) 125 in a mixture of ethanol/ethylacetate 1:1 10% Pd/C (40 mg) was added. The flask was flushed 3 times with hydrogen and filled with hydrogen at 30 to 35 psi. The suspension was stirred vigorously at room temperature for 30 minutes. The catalyst was filtered off, the filtrate was evaporated in vacuo to dryness. The solid 126 was used for the next step without purification

후처리

  1. additionwas added
  2. customThe flask was flushed 3 times with hydrogen
  3. additionfilled with hydrogen at 30 to 35 psi
  4. filtrationThe catalyst was filtered off
  5. customthe filtrate was evaporated in vacuo to dryness
  6. customThe solid 126 was used for the next step without purification

출처 및 근거

ORD 기록
ord-0a32027934d040a7aa8d963634b79be9
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06906103B2

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