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Potassium Carbonate → HCID 15512465, 화합물

HRID 1071981
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HRID 1071981 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11]Br)=[CH:2]1.[NH:13]1[CH2:18][CH2:17][CH:16]([NH:19]C(=O)OC(C)(C)C)[CH2:15][CH2:14]1.C(=O)([O-])[O-].[K+].[K+].S([O-])([O-])(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC.C([N+](CCCC)(CCCC)CCCC)CCC>O.C1(C)C=CC=CC=1>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11][N:13]2[CH2:18][CH2:17][CH:16]([NH2:19])[CH2:15][CH2:14]2)=[CH:2]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 11430Potassium CarbonateHCID 7238334-(N-Boc-amino)piperidineHCID 11433187Bis(tetrabutylammonium) sulphateHCID 150754803-(2-bromoethyl)Benzofuran

생성물 1

HCID 15512465HCID 15512465, 화합물

시약·촉매·용매 2

HCID 962Water용매
HCID 1140
Toluene
용매

실험 절차

10 mmol of 2-(benzofuran-3-yl)-1-bromoethane, 9.62 mmol of tert-butyl 4-piperidyl-carbamate, 2.65 g of potassium carbonate and 0.65 g of tetrabutylammonium sulphate are added to 10 ml of toluene. After refluxing for 12 hours, the mixture is taken up in water. The organic phase is then washed with water, dried and then filtered. Evaporation under reduced pressure allows the expected product to be isolated.

후처리

  1. temperatureAfter refluxing for 12 hours
  2. washThe organic phase is then washed with water
  3. customdried
  4. filtrationfiltered
  5. customEvaporation under reduced pressure
  6. customto be isolated

출처 및 근거

ORD 기록
ord-33c732245465467fa3295518d835bccd
출처 데이터셋
uspto-grants-2005_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06908922B2

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