Bromine → alpha-Bromo-2'-fluoro-4'-chloropropoxyacetophenone

HRID 1072028

반응식

HRID 1072028 반응식
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH2:10][CH2:11][Cl:12])[CH:5]=[CH:4][C:3]=1[C:13](=[O:15])[CH3:14].[Br:16]Br.C(=O)(O)[O-].[Na+]>CCOCC>[Br:16][CH2:14][C:13]([C:3]1[CH:4]=[CH:5][C:6]([O:8][CH2:9][CH2:10][CH2:11][Cl:12])=[CH:7][C:2]=1[F:1])=[O:15]

참가 물질

5

반응물 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 69375838HCID 69375838, 화합물

생성물 1

HCID 22015593alpha-Bromo-2'-fluoro-4'-chloropropoxyacetophenone

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of the product of Step A (2.3 g) in ether (10 mL) was treated with bromine (0.51 mL) and the mixture stirred for approximately 17 hours. The mixture was slowly poured into saturated sodium bicarbonate solution (40 mL) and then the organic layer was separated. The aqueous layer was washed with a fresh portion of ether (40 mL). The combined organic layers were washed with a fresh portion of water (50 mL), dried over magnesium sulfate, filtered and evaporated to give the title compound (3.1 g).

후처리

  1. customthe organic layer was separated
  2. washThe aqueous layer was washed with a fresh portion of ether (40 mL)
  3. washThe combined organic layers were washed with a fresh portion of water (50 mL)
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-6b55dccd5c954e5d98951512d70960b1
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06908929B2

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